Publications

The list below contains the some of the more important scientific papers on epilepsy to which our doctors have contributed. The links will take to you to Pubmed abstracts of the studies or a complete report when available.

We Are Failing Our Patients: Guidelines and Quality Measures
Robert J. Gumnit, MD
Epilepsia Editorial 2010 Nov;51(11):2361-3

Caring for the Patient with Seizures: A 21st Century Approach
Robert J. Gumnit, MD
Minnesota Medicine

New Approaches, Rooted in Experience.
Thaddeus S. Walczak, M.D.
Minnesota Physicians

Intravenous topiramate: Safety and pharmacokinetics following a single dose in patients with epilepsy or migraines taking oral topiramate.
Clark AM, Kriel RL, Leppik IE, White JR, Henry TR, Brundage RC, Cloyd JC.
Epilepsia. 2013 Apr 15. doi: 10.1111/epi.12165  

Do antiepileptic drugs or generalized tonic-clonic seizure frequency increase SUDEP risk? A combined analysis.
Hesdorffer DC, Tomson T, Benn E, Sander JW, Nilsson L, Langan Y, Walczak TS, Beghi E, Brodie MJ, Hauser WA
Epilepsia. 2012 Feb;53(2):249-52

Challenges of epilepsy in elderly people.
Leppik IE, Walczak TS, Birnbaum AK.
Lancet. 2012 Sep 29;380(9848):1128-30 

Long-term association between seizure outcome and depression after resective epilepsy surgery.
Hamid H, Liu H, Cong X, Devinsky O, Berg AT, Vickrey BG, Sperling MR, Shinnar S, Langfitt JT, Walczak TS, Barr WB, Dziura J, Bazil CW, Spencer SS
Neurology. 2011 Nov 29;77(22):1972-6. 

Canine status epilepticus: a translational platform for human therapeutic trials.
Leppik IE, Patterson EN, Coles LD, Craft EM, Cloyd JC.
Epilepsia. 2011 Oct;52 Suppl 8:31-4 

Combined analysis of risk factors for SUDEP.
Hesdorffer DC, Tomson T, Benn E, Sander JW, Nilsson L, Langan Y, Walczak TS, Beghi E, Brodie MJ, Hauser A; ILAE Commission on Epidemiology; Subcommission on Mortality.
Epilepsia. 2011 Jun;52(6):1150-9. 

Quality improvement in neurology: AAN epilepsy quality measures: Report of the Quality Measurement and Reporting Subcommittee of the American Academy of Neurology.
Fountain NB, Van Ness PC, Swain-Eng R, Tonn S, Bever CT Jr; American Academy of Neurology Epilepsy Measure Development Panel (including Walczak TS)
Neurology. 2011 Jan 4;76(1):94-9 

Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy.
Engel J Jr, McDermott MP, Wiebe S, Langfitt JT, Erba G, Gardiner I, Stern J, Dewar S, Sperling MR, Jacobs M, Kieburtz K; Early Randomized Surgical Epilepsy Trial (ERSET) Study Group(including Walczak TS)
Epilepsia. 2010 Oct;51(10):1978-86 

Intramuscular and intravenous levetiracetam in humans: safety and pharmacokinetics.
Leppik IE, Goel V, Rarick J, Nixdorf DR, Cloyd JC.
Epilepsy Res. 2010 Oct;91(2-3):289-92 

Antiepileptic drug use and rates of hip bone loss in older men: a prospective study.
Ensrud KE, Walczak TS, Blackwell T, Ensrud ER, Bowman PJ, Stone KL.
Neurology. 2008 Sep 2;71(10):723-30 

Employment outcomes following resective epilepsy surgery.
Chin PS, Berg AT, Spencer SS, Sperling MR, Haut SR, Langfitt JT, Bazil CW, Walczak TS, Pacia SV, Vickrey BG.
Epilepsia. 2007 Dec;48(12):2253-7 

Patient-perceived impact of resective epilepsy surgery.
Chin PS, Berg AT, Spencer SS, Lee ML, Shinnar S, Sperling MR, Langfitt JT, Walczak TS, Pacia SV, Bazil CW, Vassar S, Vickrey BG.
Neurology. 2006 Jun 27;66(12):1882-7  

Reduction of AEDs in postsurgical patients who attain remission.
Berg AT, Vickrey BG, Langfitt JT, Sperling MR, Shinnar S, Bazil C, Walczak T, Spencer SS; Multicenter Study of Epilepsy Surgery.
Epilepsia. 2006 Jan;47(1):64-71 

Changes in depression and anxiety after resective surgery for epilepsy.
Devinsky O, Barr WB, Vickrey BG, Berg AT, Bazil CW, Pacia SV, Langfitt JT, Walczak TS, Sperling MR, Shinnar S,
Spencer SS.
Neurology. 2005 Dec 13;65(11):1744-9 

Predicting long-term seizure outcome after resective epilepsy surgery: the multicenter study.
Spencer SS, Berg AT, Vickrey BG, Sperling MR, Bazil CW, Shinnar S, Langfitt JT, Walczak TS, Pacia SV;
Multicenter Study of Epilepsy Surgery.
Neurology. 2005 Sep 27;65(6):912-8. 

Sudden unexpected death in epilepsy: a review of incidence and risk factors.
Tomson T, Walczak T, Sillanpaa M, Sander JW.
Epilepsia. 2005;46 Suppl 11:54-61 

Antiepileptic drug use increases rates of bone loss in older women: a prospective study.
Ensrud KE, Walczak TS, Blackwell T, Ensrud ER, Bowman PJ, Stone KL.
Neurology. 2004 Jun 8;62(11):2051-7. 

Advances in antiepileptic drug treatments. A rational basis for selecting drugs for older patients with epilepsy.
Leppik IE, Bergey GK, Ramsay RE, Rowan AJ, Gidal BE, Birnbaum AK, Elliott MB.
Geriatrics. 2004 Dec;59(12):14-8, 22-4

Levetiracetam and partial seizure subtypes: pooled data from three randomized, placebo-controlled trials.
Leppik IE, Biton V, Sander JW, Wieser HG.
Epilepsia. 2003 Dec;44(12):1585-7. 

Classification of the myoclonic epilepsies.
Leppik IE
Epilepsia. 2003;44 Suppl 11:2-6 

Initial outcomes in the Multicenter Study of Epilepsy Surgery.
Spencer SS, Berg AT, Vickrey BG, Sperling MR, Bazil CW, Shinnar S, Langfitt JT, Walczak TS, Pacia SV, Ebrahimi N, Frobish D; Multicenter Study of Epilepsy Surgery.
Neurology. 2003 Dec 23;61(12):1680-5. 

How long does it take for partial epilepsy to become intractable?
Berg AT, Langfitt J, Shinnar S, Vickrey BG, Sperling MR, Walczak T, Bazil C, Pacia SV, Spencer SS
Neurology. 2003 Jan 28;60(2):186-90. 

Cost-effective therapies in nursing home patients with epilepsy and seizures.
(No abstract available, article requires subscription)
Leppik IE, Cloyd JC.
J Am Med Dir Assoc. 2002 Jul-Aug;3(4 Suppl):H12-6 

Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study.
Walczak TS, Leppik IE, D'Amelio M, Rarick J, So E, Ahman P, Ruggles K, Cascino GD, Annegers JF, Hauser WA.
Neurology. 2001 Feb 27;56(4):519-25. 

Reduction of rapid eye movement sleep by diurnal and nocturnal seizures in temporal lobe epilepsy
Bazil CW, Castro LH, Walczak TS
Archives of Neurology 2000;57:363-368

Relationships between seizure severity and health-related quality of life in refractory localization-related epilepsy.
Vickrey BG, Berg AT, Sperling MR, Shinnar S, Langfitt JT, Bazil CW, Walczak TS, Pacia S, Kim S, Spencer SS
Epilepsia 2000;41:760-764

Driving in adults with refractory localization-related epilepsy. Multi-Center Study of Epilepsy Surgery.
Berg AT, Vickrey BG, Sperling MR, Langfitt JT, Bazil CW, Shinnar S, Walczak TS, Pacia S, Spencer SS.
Neurology 2000;54:625-630

Multivariable Prediction of seizure outcome one year after resective epilepsy surgery:
Development of a model with independent validation

Berg AT, Walczak TS, Hirsch LJ, Spencer SS
Epilepsy Research 1998;29:185-194

Outcome after diagnosis of psychogenic non-epileptic seizures
Walczak TS, Papacostas S, Williams DT, Scheuer ML, Lebowitz N, Notarfrancesco A
Epilepsia 1995;36:1131-1137

Positron emission tomography predicts surgical outcome in temporal lobectomy
Radtke RA, Hanson MW, Hoffman JM, Crain RJ, Walczak TS, Lewis DV, Beam C, Coleman RE, and Friedman AF
Neurology 1993;43(6):1088-1092

Anterior temporal lobectomy for complex partial seizures:
evaluation, results, and long term follow-up in 100 cases

Walczak TS, Radtke R, Lewis DV, McNamara JO, Thompson E, Friedman A, and Nashold BS
Neurology 1990;40:413-418

A prospective study on sudden unexpected death in epilepsy
Leestma JE, Walczak TS, Hughes JR, Kallelkar MB, Teas SS
Annals of Neurology 1988;26:195-203